El Rol de la Gonadotropina Coriónica Humana en la fisiopatología tumoral (Mecanismos moleculares de la ?-hCG en la progresión, invasión y metástasis de tumores).

Nicole Lagos Ruiz

Authors

Nicole Lagos Ruiz Uleam

Abstract

Cancer has become one of the leading causes of death worldwide, with statistics rising proportionally over time, attribute to the general aging of the population and poor personal habits. This has led to the search for specific markers that aid in the diagnosis, prognosis, and monitoring of the disease, among which in the alteration of the levels of the beta subunit of human chorionic gonadotropin. This systematic review aims to establish the role this hormone plays in the progression, invasion, and metastasis of tumors. A systematic review of scientific databases such as PubMed, SciELO, and Google Scholar was conducted to obtain relevant information for the study. The research revealed the fact that the excessive presence of the hormone in a tumor environment leads to better proliferation, invasion, and metastasis of tumors when it binds to its LH/HCG receptor, activating ERK1/2 and MMP-2 signaling pathways.

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References

REFERENCIAS BIBLIOGRÁFICAS.

Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R., Soerjomataram, I., & Jemal, A. (2024). Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 229-263. doi:https://doi.org/10.3322/caac.21834

Campoverde, F., & Campoverde, N. (2020). La tasa de Mortalidad General del Ecuadordel INEC subestima erróneamente al Cáncer. Rev. Oncol. Ecu, 30(3), 178-191. doi:10.33821/488

Grenache, D. (2020). Progress in understanding the use of human chorionic gonadotropin as a tumor marker. Clinical Chemistry and Laboratory Medicine (CCLM),, 58(3), 323-325. doi:https://doi.org/10.1515/cclm-2019-1288

Guo, X., Liu, G., Schauer, I., Yang, G., Mercado-Uribe, I., Yang, F., . . . Liu, J. (2011). Overexpression of the ? subunit of human chorionic gonadotropin promotes the transformation of human ovarian epithelial cells and ovarian tumorigenesis. The American journal of pathology, 179(3), 1385–1393. doi: https://doi.org/10.1016/j.ajpath.2011.05.018

Kölbl, A., Schlenk, K., Behrendt, N., & Andergassen, U. (2017). The importance of hCG in human endometrial adenocarcinoma and breast cancer. The International Journal of Biological Markers., 33(1), 33-39. doi:doi:10.5301/ijbm.5000290

Liu, N., Peng, S., Zhan, G., Yu, J., Wu, W., Gao, H., . . . Guo, X. (2017). Human chorionic gonadotropin ? regulates epithelial-mesenchymal transition and metastasis in human ovarian cancer. Oncology reports, 38(3), 1464–1472. doi:https://doi.org/10.3892/or.2017.5818

Nwabuobi, C., Arlier, S., Schatz, F., Guzeloglu-Kayisli, O., Lockwood, C. J., & Kayisli, U. A. (2017). hCG: Biological Functions and Clinical Applications. International Journal of Molecular Sciences, 38(10), 2037. doi: https://doi.org/10.3390/ijms18102037

Ogino, M., & Tadi, P. (2025). Physiology, Chorionic Gonadotropin. En T. I. (FL), StatPearls. doi:https://www.ncbi.nlm.nih.gov/books/NBK556118/

Parra-Soto, S., Petermann-Rocha, F., Martínez-Sanguine, M., Leiva-Ordeñez, A., Troncoso-Pantoja, C., Ulloa, N., . . . Celis-Morales, C. (2020). Cáncer en Chile y en el mundo: una mirada actual y su futuro escenario epidemiológico. Rev Med Chile, 148, 1489-1495.

Schüler-Toprak, S., Treeck, O., & Ortmann, O. (2017). Human Chorionic Gonadotropin and Breast Cancer. International Journal of Molecular Sciences, 18(7), 1587. doi:https://doi.org/10.3390/ijms18071587

Siegel, R., Miller, K., Fuchs, H., & Jemal, A. (2022). Cancer statistics, 2022. CA Cancer J Clin, 7-33. doi:https://doi.org/10.3322/caac.21708

Soerjomataram, I., & Bray, F. (2021). Planning for tomorrow: global cancer incidence and the role of prevention 2020–2070. Nature Reviews Clinical Oncology, 18, 663–672.

Wu, W., Gao, H., Li, X., Peng, S., Yu, J., Liu, N., . . . Guo, X. (2018). ?-hCG promotes epithelial ovarian cancer metastasis through ERK/MMP2 signaling pathway. Cell Cycle, 18(1), 46–59. doi:https://doi.org/10.1080/15384101.2018.1558869