SYNTHESIS AND CHARACTERIZATION OF COBALT (II) COMPLEXES WITH ORGANIC BINDERS AND ANTIMICROBIAL EVALUATION

Abstract

Medicinal Inorganic Chemistry is one of the areas of Coordinating Chemistry that has been presenting advances in the elucidation of new pharmaceuticals with biological activity from metallic complexes. In view of this, the objective of this study was to synthesize two cobalt complexes with the ligands 1-(1-Feniletilideno) Carbonohidrazida (LDC) and with the ligand 1.10-phenanthroline, to perform the spectroscopic and thermogravimetric characterisations, thus how to evaluate the antibacterial activity of the ligand and the complexes in the face of the Escherichia coli bacterium. The synthesis of two complexes was carried out from the adaptation of the synthetic route available in the literature. The complexes obtained were characterized by spectroscopy in the ultraviolet-visible region, as well as by infrared spectroscopy and thermogravimetry. The biological activity occurred in vitro by the method of diffusion in disk, in front of bacterial strain Escherichia Coli. The LDC presented two bands in the Ultraviolet region (180 nm & 380 nm), not being verified absorption in the region of the visible (380 nm & 780 nm), because the compound did not present color. It was found that in the infrared region, the band of the complexes is shifted to Higher energy region (greater wave number), this indicates that the metallic ion is coordinated to the oxygen of C = O. The Termogravimétricas evaluations allowed to indicate the actual composition of the synthesized complexes. The ligand did not present inhibition before the bacterium, complex I and complex II demonstrated activity in the face of bacterial strain.